Chloroform HPLC
Chloroform HPLC grade is a high-purity, chlorinated organic solvent extensively utilized in analytical chemistry and various laboratory applications.
Description
Chloroform, with the chemical formula CHCl3 and CAS number 67-66-3, is a colorless, dense, and volatile liquid possessing a characteristic ethereal odor. This HPLC (High Performance Liquid Chromatography) grade product signifies a rigorously purified form, ensuring minimal impurities that could interfere with sensitive analytical techniques. Chloroform is miscible with most organic solvents but sparingly soluble in water. Its molecular structure consists of a central carbon atom bonded to one hydrogen atom and three chlorine atoms, contributing to its nonpolar nature and effectiveness as a solvent for a wide range of organic compounds. Due to its excellent solvent properties, high density, and relatively low boiling point, chloroform is a valuable reagent in research, development, and quality control laboratories, particularly where precise chromatographic separations and spectroscopic analyses are performed.
Applications
Chloroform finds extensive application in analytical chemistry as a solvent for spectroscopy (e.g., NMR, IR), and particularly in HPLC and GC analysis where high purity is paramount to prevent interference and ensure accurate results. It serves as an extractant for various organic compounds from aqueous solutions in pharmaceutical and chemical industries. Additionally, it is used as a solvent for fats, oils, resins, and alkaloids. Historically, it was used as an anesthetic, though this application has been largely replaced due to toxicity concerns. In certain industrial settings, it may still be employed as a solvent in the manufacturing of certain products, adhering to strict safety protocols.
Storage & Handling
Store in tightly sealed containers in a cool, well-ventilated area, away from direct sunlight, heat, and incompatible materials. Keep containers securely closed to prevent evaporation and minimize exposure. Handle with appropriate personal protective equipment in a fume hood.
Danger
- H301 Toxic if swallowed
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