Acetylsalicylic Acid USP
Acetylsalicylic Acid USP (CAS 50-78-2) is a high-purity pharmaceutical intermediate, essential for various therapeutic formulations.
Description
Acetylsalicylic Acid, with CAS number 50-78-2 and chemical formula C9H8O4, is a well-established pharmaceutical intermediate conforming to United States Pharmacopeia (USP) standards. This compound is chemically characterized as an ester of acetic acid and salicylic acid. It is synthesized primarily through the esterification of salicylic acid with acetic anhydride under controlled conditions, followed by purification processes to achieve the required USP grade. Its molecular weight is approximately 180.16 g/mol. The production process involves careful monitoring of reaction parameters, including temperature, pressure, and catalyst concentration, to ensure high yields and purity. Post-synthesis, thorough quality control measures, including chromatographic techniques and spectroscopic analyses, are employed to verify its identity, purity, and absence of impurities. It is generally supplied as a white, crystalline powder, known for its stability under specified storage conditions. Its chemical structure confers distinct medicinal properties, making it a cornerstone in pharmaceutical manufacturing.
Applications
Acetylsalicylic Acid serves as a critical pharmaceutical intermediate predominantly in the synthesis of analgesic, antipyretic, and anti-inflammatory medications. Its primary application lies in the production of aspirin, a widely used non-steroidal anti-inflammatory drug (NSAID) prescribed for pain relief, fever reduction, and treatment of inflammatory conditions like arthritis. Beyond its conventional uses, it is also utilized in the formulation of antiplatelet agents for cardiovascular disease prevention, inhibiting platelet aggregation to reduce the risk of thrombotic events. Furthermore, it finds niche applications in veterinary medicine and as a reagent in certain laboratory procedures, although its bulk usage is overwhelmingly in human pharmaceutical manufacturing. Its consistent quality and well-documented efficacy make it an indispensable compound in the global pharmaceutical industry.
Storage & Handling
Store in a tightly closed container in a cool, dry, and well-ventilated area, away from incompatible materials. Protect from moisture and direct sunlight. Handle with appropriate personal protective equipment to avoid inhalation, ingestion, or skin contact.
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